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Clozapine ( Clozaril ) is part of a special monitoring program called the clozapine ( Clozaril ) REMS Program because of its risk for low white blood cells and infection You'll need to get blood tests before you start this medication and before every refill Clozaril ( clozapine ) is an antipsychotic medication that is used to treat severe schizophrenia symptoms in people who have not responded to other medications Clozaril is also used to help reduce the risk of suicidal behavior in people with schizophrenia or similar disorders The starting dose is 12 5 mg once daily or twice daily The total daily dose can be increased in increments of 25 mg to 50 mg per day, if well-tolerated, to achieve a target dose of 300 mg to 450 mg per day (administered in divided doses) by the end of 2 weeks Subsequently, the dose can be increased once weekly or twice weekly, in increments See the FDA REMS page ( [Web] ) (Also see REMS under Dosage and Administration ) Side effects include: Sedation, dizziness vertigo, headache, tremor, tachycardia, hypotension, syncope, hypersalivation, sweating, dry mouth, visual disturbances, constipation, nausea, fever CLOZARIL ® ( clozapine ) is an atypical antipsychotic indicated for: The treatment of severely ill patients with schizophrenia who fail to respond adequately to standard antipsychotic treatment; Reduction in the risk of recurrent suicidal behavior in schizophrenia or schizoaffective disorder Clozaril is used to treat schizophrenia in adults after other treatments have failed Clozaril is available only from a certified pharmacy under a special program Clozaril is also used to reduce the risk of suicidal behavior in adults with schizophrenia or similar disorders Warnings Clozaril affects your immune system Clozapine is a psychiatric medication (anti-psychotic type) that works by helping to restore the balance of certain natural substances (neurotransmitters) in the brain Clozapine decreases

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